Overview:
Recent research has indicated that hydrostatic pressure may be an important stimulus for developing functional tissues. Hydrostatic pressure can mimic the environment of the native tissue and promote mechanical signals to accelerate and enhance tissue regeneration. To accommodate these research interests TGT now offers the CartiGen HP bioreactor system. The CartiGen HP imparts a controlled static or dynamic pressure to a sample of any geometry.  The pressure subjects the developing tissue or cells to a hydrostatic state of stress. Applications include investigating cell function, modulating the growth and development of engineered tissues, or testing drugs and regenerative medicine technologies.

Fabricated from autoclavable materials, each chamber is compatible with standard 6, 12, 24, or 96 well tissue culture plates.  The standard system can accommodate multiple chambers for increased sample counts. Designed for placement within a standard incubator, the modular design allows installation of the cell seeded scaffold independent of the stimulation system.The CartiGen HP bioreactor system includes a pressurization system and servo-manifold. Incubator air is first pressurized and then routed to the manifold where the pressure is controlled and the desired profile generated using the GrowthWorks control system.   Using this approach, static, sinusoidal or complex pressure waveforms can be created.  The controlled pressurized air is then routed to the chamber(s) for stimulation. The standard system generates pressure to 68 psi (0.47MPa) and higher pressures are available upon request.  To mitigate changes to the chamber media temperature, the pressurization system also provides temperature control of the air.

Chamber Dimensions:
H x 10.2"(259mm);L x 5.5"(140mm);W x 4.4"(112mm); Weight: 6.6lbs (3.0kg)