The LumeGen system imparts mechanical pulsatile pressure to a 3D sample. TGT's patented technology. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. The LumeGen's patented technology, US Patent # 7348175, employs pressure control to deliver user defined pressure wave forms of physiological magnitude. It is integrated with a computer controlled mean flow pump and is capable of low or high-flow configurations. TGT customers are currently utilizing these systems in a wide range of research areas including:
Systems range from compact, single chamber systems to versatile and powerful six chamber systems.
1V LumeGen Bioreactor
The 1V system has been designed as a simple bioreactor system that is able to support a wide range of basic pulsatile pressure and shear stress cell and tissue growth experiments via user defined stimulation protocols. This allows the possibility of adding optional features (transducers, non-contact micrometers, pressure sensors, etc.) and modules to customize the tool to specific needs.
6Vc LumeGen Bioreactor
The LumeGen 6Vc Vascular System integrates the necessary bioreactor components into a compact and manageable system. The 6Vc compact design fits easily into a standard incubator and can be autoclaved fully assembled. The versatile chamber configuration provides individual flow loops to each sample.
Click here to download a LumeGen Brochure (Adobe PDF 144kb)
| VASCULAR | ||
| Key: S=Standard, A=Available, - = not available | ||
| CHAMBERS | 1V | 6Vc |
| Individual vascular growth chamber | S | S |
| 6 parallel vascular growth chambers | - | S |
| Sample grips for 3, 4, 5, 6 mm lumen diameter | S | S |
| External lumen instrumentation ports per chamber | 3 | 3 |
| Internal lumen instrumentation ports per chamber | 2 | 2 |
| O-ring style sample fixation | A | A |
| Patent pending grip lock during sample handling | S | S |
| Lumen/ablumen volume isolators/reducers for scaffold seeding | A | A |
| STIMULATION | ||
| Static pressure control (200 mm Hg peak pressure) | A | A |
| Pulsatile pressure control (sinusoidal) | A | S |
| Pulsatile pressure control (physiological content, user defined waveform) | A | S |
| Axial distension stimulation | A | A |
| CONTROLS | ||
| Controller software, computer, and monitor | S | S |
| Power supplies and cabling | S | S |
| Mean cell culture media flow control | A | S |
| Dynamic cell culture media flow control | A | S |
| TISSUE MONITORING | ||
| Non-contact radial or axial distension measurement | A | A |
| Non-contact flow sensors | A | A |
| Catheter pressure transducers | A | A |
| ACCESSORIES | ||
| Media reservoir | S | S |
| Incubator | A | A |
| BENEFITS | ||
| All-autoclavable components | S | S |
| Excellent sample visibility | S | S |
| Media change without opening reservoir via luer fittings | S | S |
| Easy rotisserie cell seeding owing to cylindrical chamber frame | S | S |
| Light weight design for easy handling | S | S |
| Transparent opposing bioreactor walls for optical inspection or measurement | S | S |
| Compact design to fit in standard incubators | S | S |
| Easily cleaned surface finishes | S | S |
| 100% satisfaction guaranteed warranty | S | S |
