Patents:
Instrumented bioreactor with material property measurment capability and process-based adjustment for conditioning tissue engineered medical products. US pat no 7410792. August 12, 2008

Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products. US pat no 7348175. March 25, 2008 
 

Peer Reviewed Publications:
Christopher M. Voge, Mihalis Kariolis, Rebecca A. MacDonald, Jan P. Stegemann, Directional Conductivity in Protein-Nanotube Biomaterials through Strain-Induced Matrix Alignment.  J Biomed Mat Res A. in press. 

Porter BD, Lin AS, Peister A, Hutmacher D, Guldberg RE, Noninvasive image analysis of 3D construct mineralization in a perfusion bioreactor. Biomaterials. 2007 May; 28(15):2525-33. Epub 2007 Jan 26.

Cartmell SH, Porter BD, Garcia AJ, Guldberg RE, Effects of Medium Perfusion Rate on Cell-Seeded Three-Dimensional Bone Constructs In Vitro. Tissue Eng. 2003 Dec;9(6):1197-203.

Presentations:
Christopher M. Voge, Mihalis Kariolis, Rebecca A. MacDonald, Jan P. Stegemann, Directional Conductivity in Protein-Nanotube Biomaterials through Strain-Induced Matrix Alignment. 8th World Biomaterials Congress. Amsterdam, Netherlands, June 2008.

S Saber. Stanford University Medical Center, Department of Plastic Surgery, Flexor Tendon Tissue Engineering: Cyclic Strain Increases Construct Strength and Tendon Architecture. Plastic Surgery Research Council. Springfield, Illinois, May 2008. Also presented at the California Society of Plastic Surgeons, Dana Point, California, June 2008.

BD Porter, A Peister, D Hutmacher, RE Guldberg, Dynamic Culture Conditions Modulate Mineralization Matrix Deposition, Growth Rate, and Particle Size Within Large 3-D Constructs. Transactions of the 2006 Summer Bioengineering Conference, Amelia Island, Florida, June 2006. 

BD Porter, A Peister, D Hutmacher, RE Guldberg, In Vitro Perfusion Accelerates the Rate of Mineralized Matrix Formation Within 3-D Constructs by Increasing both the Number and Size of Mineralization Sites. Transactions of the 52nd Annual Orthopaedic Research Society, Chicago, Illinois, March 2006.

BD Porter, Roger Zauel, D Hutmacher, RE Guldberg, D Fyhrie, Perfusion Significantly Increases Mineral Production Inside 3-D PCL Composite Scaffolds. Regenerate International Conference and Exposition, Atlanta, Georgia, June 2005. Also presented at the American Society for Mechanical Engineering Summer Bioengineering Meeting, Vail, Colorado, June 2005. Also presented at Transactions of the 51st Annual Orthopaedic Research Society Meeting, Washington, D.C., February 2005.

Posters:
S.E.McIlhenny, D.J.Grabo, N.A. Tarola, P.Zhang, I.M.Shapiro, T.N.Tulenko, and P.J.DiMuzio,  Shear Conditioning of Adipose-Derived Stem Cells Increases Retention on Decellularized Vein Grafts. Biomedical Engineering Society Meeting, Los Angeles, California, September 2007. 

Whitlcok, Patrick, Knutson, James, Smith, Thomas L., Van Dyke Mark E., Shilt, Jeffrey S., Koman, L. Andrew, Poehling, Gary G., Effects of Mechanical Stimulation on a Cell-Seeded Scaffold Developed for Tendon and Ligament Regeneration. Transactions of the 6th Combined Meeting of the Orthopaedic Research Society, Honolulu, Hawaii, October 2007. Also presented at the Transactions of the 54th Annual Orthopaedic Research Society Meeting, San Francisco, California, March 2008.

Mechanical Stimulation in the Literature
Reviews:
Barrilleaux, B., et al. 2006. Tissue Engineering. Review: of Ex Vivo Engineering of Living Tissues with Adult Stem Cells. Oct 1 (on line publishing).

Bilodeau, K. and  Mantovani, D. 2006. Tissue Engineering. Bioreactors for tissue engineering focus on mechanical constraints, A comparative review. Aug: 12 (8) 2367-83.

Ratner, B., et al. 1996. Biomaterials Science: An Introduction to Materials in Medicine. Academic Press. San Diego, CA.

Wendt, D., et. al. . 2006. Biorheology. Uniform tissues engineered by seeding and culturing cells in 3D scaffolds under perfusion at defined oxygen tensions. 43 (3-4): 418-488.

Bone
Braccini, A. et al. 2005. Stem Cells. Three-dimensional perfusion culture of human bone marrow cells and generation of osteoinductive grafts. Sep 23 (8): 1066-72.

Vascular
Shinoka, T. 2002. Artificial Organs. Tissue Engineered Heat Valves: Autologous Cell Seeding on Biodegradable Polymer Scaffold. 26(5): 402-406.

Yow, K.H., et al. 2006. British Journal of Surgery. Tissue engineering of vascular conduits. 93(6): 652-661.

Stem Cell
Willenberg, B.J., et al. 2006. Journal of Biomaterials Res A. Self-assembled copper-capillary alginate gel scaffolds with oligochitosan support embryonic stem cell growth. 79(2): 440-50.